- Search results for K04905
Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
29 products were found matching "K04905"!
Close filters
Filter by:
No results were found for the filter!
Item number: NSJ-RQ7086
0.5mg/ml if reconstituted with 0.2ml sterile DI water. KCNH2, also known as ERG-1, H-ERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier...
Keywords: | Anti-ERG, Anti-KCNH2, Anti-H-ERG, Anti-hERG1, Anti-ERG-1, Anti-hERG-1, Anti-Eag homolog, Anti-Eag-related protein 1,... |
Application: | WB, FC, Direct ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
755.00€
*
Item number: Cay39375-1
SLU-10482 is an antiparasitic agent. It reduces the number of C. parvum parasites in HCT-8 cells (EC50 = 0.07 µM). SLU-10482 binds to human ether-a-go-go (hERG, Kd = 43 µM) to a lesser extent than the antiparasitic SLU-2633. In vivo, SLU-10482 (5 and 15 mg/kg twice per day) decreases the number of fecal oocysts in a...
Keywords: | 2-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[4-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1-piperazinyl]-ethanone |
Application: | Antiparasitic agent |
CAS | 2755451-45-5 |
MW: | 408.4 D |
From 35.00€
*
Item number: Cay15213-500
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In addition, amiodarone binds with high affinity to the sigma-1...
Keywords: | (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride |
Application: | Ion channel blocker |
CAS | 19774-82-4 |
MW: | 681.8 D |
From 43.00€
*
Item number: Cay15203-5
Voltage-gated potassium ERG channels (Kv11.1), encoded by the ether-a-go-go related gene, mediate the inwardly rectifying potassium (K+) current that repolarizes myocardial cells, gut smooth muscle cells, and interstitial cells of Cajal. E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs...
Keywords: | N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-methanesulfonamide, dihydrochloride |
Application: | ERG K+ channel blocking |
CAS | 113559-13-0 |
MW: | 474.4 D |
From 109.00€
*
Item number: Cay26451-1
Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Cay-15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed...
Keywords: | N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-d4]amino]ethyl]phenyl]-methanesulfonamide |
Application: | GC-MS, LC-MS, Quantification, Internal standard, Voltage-gated potassium channel (KCNH2) blocker |
CAS | 1189700-56-8 |
MW: | 445.6 D |
From 205.00€
*
Item number: BPS-60619
Human ERG channel has been stably expressed in HEK293 cell line and its expression was confirmed by Western blotting. The channel activity of hERG was characterized by a fluorescence-based assay using thallium influx as a surrogate indicator of potassium ion channel activity coupled with a thallium-sensitive...
Keywords: | ERG, H-ERG, hERG1, KCNH2, ERG-1, hERG-1, Eag homolog, Eag-related protein 1, Ether-a-go-go-related protein 1,... |
Species reactivity: | human |
2,609.00€
*
Item number: Cay15045-10
Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 µM, dofetilide has pro-arrhythmic activity,...
Keywords: | Tikosyn, UK 68789, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide |
Application: | Voltage-gated potassium channel (KCNH2) blocker |
CAS | 115256-11-6 |
MW: | 441.6 D |
From 84.00€
*
Item number: Cay20343-10
NS 1643 is an activator of the human ether-a-go-go related gene (ERG1, KCNH2, hERG) KV11.1 channel (EC50 = 10.5 µM). It also activates the KV11.2 (ERG2, KCNH6) channel, but evokes a distinctly different response from that of KV11.1. NS 1643 is commonly used in cells or isolated tissues.Formal Name:...
Keywords: | N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-urea |
Application: | KCNH2 activator |
CAS | 448895-37-2 |
MW: | 380.2 D |
From 60.00€
*
Item number: LKT-S5976.25
Is a hypertension and cardiac arrhythmias. Inhibits the potassium channels in the heart. The L-form of this compound is also a beta blocker.
Keywords: | Sotalol (hydrochloride) |
CAS | 959-24-0 |
MW: | 308,82 D |
From 149.00€
*
Item number: Cay22260-10
Cyclovirobuxine D (CVB-D) is an alkaloid, and the main active component of the traditional Chinese medicine B. microphylla, that has diverse biological activities. It is an ether-a-go-go related gene (ERG) potassium channel blocker with an IC50 value of 19.7 µM using whole-cell patch-clamp electrophysiology in...
Keywords: | CVB-D, NSC 91722, (3beta,5alpha,16alpha,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol |
Application: | KCNH2 blocker |
CAS | 860-79-7 |
MW: | 402.7 D |
From 54.00€
*
Item number: Cay15011-100
(±)-Ibutilide is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM. (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular...
Keywords: | U-70226E, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide, 2E-butenedioate (2:1) |
Application: | Potassium channel blocker |
CAS | 122647-32-9 |
MW: | 442.6 D |
From 114.00€
*
Item number: Cay20997-1
Nifekalant is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed rectifier potassium channel (IKr, IC50 = 10 µM) and prolongs cardiac action potential duration (APD) in isolated dog Purkinje fibers when used at concentrations of 1 and 3 µg/ml. Nifekalant (3 mg/kg) inhibits arrhythmias...
Keywords: | 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione, monohydrochloride |
Application: | Ikr blocker |
CAS | 130656-51-8 |
MW: | 441.9 D |
From 43.00€
*