DC260126

DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Cay-90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively. At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic beta-cell apoptosis in obese diabetic db/db mice.Formal Name: N-(4-butylphenyl)-4-fluoro-benzenesulfonamide. CAS Number: 346692-04-4. Molecular Formula: C16H18FNO2S. Formula Weight: 307.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 100 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: FC1=CC=C(S(NC2=CC=C(CCCC)C=C2)(=O)=O)C=C1. InChi Code: InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3. InChi Key: CNGHPXKWPGIDSK-UHFFFAOYSA-N.