24 products were found matching "K04325"!

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HWL-088
HWL-088

Item number: Cay30227-1

HWL-088 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40) and peroxisome proliferator-activated receptor delta (PPARdelta). It induces calcium mobilization in CHO cells expressing human FFAR1/GPR40 (EC50 = 18.9 nM) and transactivation of PPARdelta in a reporter assay using HEK293 cells (EC50 = 570.9 nM)....
Keywords: 2-[2-fluoro-4-[(2'-methyl[1,1'-biphenyl]-3-yl)methoxy]phenoxy]-acetic acid
Application: FFAR1(GPR40)/PPARdelta agonist
CAS 2378617-96-8
MW: 366.4 D
From 106.00€ *
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Rat FFAR1 (Free Fatty Acid Receptor 1) ELISA Kit
Rat FFAR1 (Free Fatty Acid Receptor 1) ELISA Kit

Item number: ELK-ELK7340.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat FFAR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat FFAR1. Next,...
Keywords: Ffar1, Gpr40, Free fatty acid receptor 1, G-protein coupled receptor 40
Application: ELISA
Species reactivity: rat
365.00€ * From 328.50€ *
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Human FFAR1 (Free Fatty Acid Receptor 1) ELISA Kit
Human FFAR1 (Free Fatty Acid Receptor 1) ELISA Kit

Item number: ELK-ELK4221.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FFAR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FFAR1. Next,...
Keywords: FFAR1, GPR40, Free fatty acid receptor 1, G-protein coupled receptor 40
Application: ELISA
Species reactivity: human
365.00€ * From 328.50€ *
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GW 1100
GW 1100

Item number: Cay10008908-5

GPR40 (free fatty acid receptor 1, FFAR1) is a G protein-coupled receptor (GPCR) that is activated by saturated and unsaturated long chain fatty acids. It is thought to play a role in the potentiation of insulin secretion by fatty acids in a glucose-sensitive manner. GW 1100 is a selective antagonist of...
Keywords: 4-[5-[(2-ethoxy-5-pyrimidinyl)methyl]-2-[[(4-fluorophenyl)methyl]thio]-4-oxo-1(4H)-pyrimidinyl]-benzoic acid, ethyl ester
Application: GPR40 antagonist
CAS 306974-70-9
MW: 520.6 D
From 98.00€ *
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FFAR1 (GPR40) Reporter Assay Kit
FFAR1 (GPR40) Reporter Assay Kit

Item number: Cay601190-1

Free fatty acid receptor 1 (FFAR1)/GPR40 is a G protein-coupled receptor for long-chain fatty acids such as docosahexaenoic acid and eicosapentaenoic acid omega-3 fatty acids. It is involved in the regulation of insulin release from pancreatic beta cells and mediates triglyceride-induced secretion of incretins GLP-1...
Keywords: Free Fatty Acid Receptor 1, G Protein-Coupled Receptor 40
Application: Cell based assays, HTS, reverse transfection reporter assay
Species reactivity: human
621.00€ *
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AMG 837
AMG 837

Item number: Cay21815-5

AMG 837 is a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40). It induces calcium mobilization in CHO cells expressing FFAR1/GPR40 but not FFAR2/GPR43, FFAR3/GPR41, or FFAR4/GPR120 (EC50s = 0.0135, >10, >10, and >10 µM, respectively). AMG 837 induces insulin secretion in MIN6 pancreatic beta-cells and...
Keywords: betaS-1-propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]-benzenepropanoic acid
Application: Partial GPR40 agonist
CAS 865231-46-5
MW: 438.4 D
From 50.00€ *
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TAK-875
TAK-875

Item number: Cay17335-1

The free fatty acid receptor 1 (FFAR1, GPR40) is highly expressed in pancreatic beta-cells and activated by medium and long-chain fatty acids. There is evidence of a link between FFAR1 (GPR40) and the ability of fatty acids to amplify glucose-stimulated insulin secretion, making this signaling pathway a potential...
Keywords: (3S)-6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid
Application: FFAR1/GPR40 agonist
CAS 1000413-72-8
MW: 524.6 D
From 60.00€ *
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DC260126
DC260126

Item number: Cay19388-5

DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Cay-90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively. At 10 mg/kg, it has been...
Keywords: N-(4-butylphenyl)-4-fluoro-benzenesulfonamide
Application: Free fatty acid receptor 1 (FFAR1/GPR40) antagonist
CAS 346692-04-4
MW: 307.4 D
From 62.00€ *
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Anti-GPR40, C-terminal
Anti-GPR40, C-terminal

Item number: ARG63777.100

Protein function: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a...
Keywords: Anti-GPR40, Anti-FFAR1, Anti-Free fatty acid receptor 1, Anti-G-protein coupled receptor 40
Application: ELISA, WB
Host: Goat
Species reactivity: human
784.00€ *
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TUG-770
TUG-770

Item number: Cay22131-1

TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells). It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a...
Keywords: 4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluoro-benzenepropanoic acid
Application: GPR40 agonist
CAS 1402601-82-4
MW: 307.3 D
From 50.00€ *
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Anti-FFAR1 (GPR40)
Anti-FFAR1 (GPR40)

Item number: Cay10007205-1

GPR40 is a seven transmembrane G Protein-coupled receptor with signalling mediated by medium- and long-chain fatty acids. Found predominantly in the beta-cells of pancreatic islets, it has been implicated in the regulation of insulin secretion. Overexpression of GPR40 in mouse beta cells leads to glucose intolerance...
Keywords: Anti-FFAR1, Anti-GPR40, Anti-Free fatty acid receptor 1, Anti-Free fatty acid receptor 1, Anti-G-protein coupled receptor...
Application: IHC, WB
Host: Rabbit
Species reactivity: human
422.00€ *
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Phytanic Acid
Phytanic Acid

Item number: LKT-P3198.25

Fatty acid metabolite of chlorophyll, RXR and PPAR agonist, potential GPR40 agonist.
Keywords: 3,7,11,15-Tetramethylhexadecanoic acid
Application: Fatty acid metabolite of chlorophyll, RXR and PPAR agonist, potential GPR40 agonist
CAS 14721-66-5
MW: 312.53 D
From 357.00€ *
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