46 products were found matching "K04325"!

TUG-469 is an agonist of free fatty aid receptor 1 (FFAR1/GPR40). It induces calcium mobilization in a reporter assay using cells expressing human FFAR1/GPR40 (EC50 = 18. nM). TUG-469 (10 µM) induces insulin secretion in INS-1E insulinoma cells. It inhibits increases in blood glucose levels in a glucose tolerance...

Recombinant CHO-K1 cells stably overexpress human free fatty acid receptor 1 (FFA1) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.

An FFAR1/GPR40 agonist, induces IP3 production in A9 cells expressing human FFAR1/GPR40 (EC50 = 3.6 nM), induces insulin secretion from pancreatic islets isolated from FFAR1 knock-in mice, reduces blood glucose levels in FFAR1 knock-in mice at 10 mg/kg

GPR40 (free fatty acid receptor 1, FFAR1) is a G protein-coupled receptor (GPCR) that is activated by saturated and unsaturated long chain fatty acids. It is thought to play a role in the potentiation of insulin secretion by fatty acids in a glucose-sensitive manner. GW 1100 is a selective antagonist of...

LY2922470 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40). It induces calcium flux in HEK293 cells expressing FFAR1/GPR40 (EC50s = 7, 1, and 3 nM for the human, mouse, and rat receptor, respectively). LY2922470 (30 mg/kg) increases blood levels of glucagon-like peptide 1 (GLP-1) in fasted mice. It also...

PBI-4050 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40) and an antagonist of G protein-coupled receptor 84 (GPR84). It induces beta-arrestin-2 recruitment in a reporter assay using HEK293 cells expressing human FFAR1/GPR40 (EC50 = 275 µM). PBI-4050 inhibits activation of GPR84 induced by decanoic acid...

Free fatty acid receptor 1 (FFAR1)/GPR40 is a G protein-coupled receptor for long-chain fatty acids such as docosahexaenoic acid and eicosapentaenoic acid omega-3 fatty acids. It is involved in the regulation of insulin release from pancreatic beta cells and mediates triglyceride-induced secretion of incretins GLP-1...

AMG 837 is a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40). It induces calcium mobilization in CHO cells expressing FFAR1/GPR40 but not FFAR2/GPR43, FFAR3/GPR41, or FFAR4/GPR120 (EC50s = 0.0135, >10, >10, and >10 µM, respectively). AMG 837 induces insulin secretion in MIN6 pancreatic beta-cells and...

The free fatty acid receptor 1 (FFAR1, GPR40) is highly expressed in pancreatic beta-cells and activated by medium and long-chain fatty acids. There is evidence of a link between FFAR1 (GPR40) and the ability of fatty acids to amplify glucose-stimulated insulin secretion, making this signaling pathway a potential...

Protein function: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a...

TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells). It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FFAR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FFAR1. Next,...