- Search results for K04325
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24 products were found matching "K04325"!
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Item number: Cay30227-1
HWL-088 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40) and peroxisome proliferator-activated receptor delta (PPARdelta). It induces calcium mobilization in CHO cells expressing human FFAR1/GPR40 (EC50 = 18.9 nM) and transactivation of PPARdelta in a reporter assay using HEK293 cells (EC50 = 570.9 nM)....
Keywords: | 2-[2-fluoro-4-[(2'-methyl[1,1'-biphenyl]-3-yl)methoxy]phenoxy]-acetic acid |
Application: | FFAR1(GPR40)/PPARdelta agonist |
CAS | 2378617-96-8 |
MW: | 366.4 D |
From 106.00€
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-10 %
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Item number: ELK-ELK7340.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat FFAR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat FFAR1. Next,...
Keywords: | Ffar1, Gpr40, Free fatty acid receptor 1, G-protein coupled receptor 40 |
Application: | ELISA |
Species reactivity: | rat |
365.00€
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From 328.50€
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Item number: ELK-ELK4221.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FFAR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human FFAR1. Next,...
Keywords: | FFAR1, GPR40, Free fatty acid receptor 1, G-protein coupled receptor 40 |
Application: | ELISA |
Species reactivity: | human |
365.00€
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From 328.50€
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Item number: Cay10008908-5
GPR40 (free fatty acid receptor 1, FFAR1) is a G protein-coupled receptor (GPCR) that is activated by saturated and unsaturated long chain fatty acids. It is thought to play a role in the potentiation of insulin secretion by fatty acids in a glucose-sensitive manner. GW 1100 is a selective antagonist of...
Keywords: | 4-[5-[(2-ethoxy-5-pyrimidinyl)methyl]-2-[[(4-fluorophenyl)methyl]thio]-4-oxo-1(4H)-pyrimidinyl]-benzoic acid, ethyl ester |
Application: | GPR40 antagonist |
CAS | 306974-70-9 |
MW: | 520.6 D |
From 98.00€
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Item number: Cay601190-1
Free fatty acid receptor 1 (FFAR1)/GPR40 is a G protein-coupled receptor for long-chain fatty acids such as docosahexaenoic acid and eicosapentaenoic acid omega-3 fatty acids. It is involved in the regulation of insulin release from pancreatic beta cells and mediates triglyceride-induced secretion of incretins GLP-1...
Keywords: | Free Fatty Acid Receptor 1, G Protein-Coupled Receptor 40 |
Application: | Cell based assays, HTS, reverse transfection reporter assay |
Species reactivity: | human |
621.00€
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Item number: Cay21815-5
AMG 837 is a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40). It induces calcium mobilization in CHO cells expressing FFAR1/GPR40 but not FFAR2/GPR43, FFAR3/GPR41, or FFAR4/GPR120 (EC50s = 0.0135, >10, >10, and >10 µM, respectively). AMG 837 induces insulin secretion in MIN6 pancreatic beta-cells and...
Keywords: | betaS-1-propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]-benzenepropanoic acid |
Application: | Partial GPR40 agonist |
CAS | 865231-46-5 |
MW: | 438.4 D |
From 50.00€
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Item number: Cay17335-1
The free fatty acid receptor 1 (FFAR1, GPR40) is highly expressed in pancreatic beta-cells and activated by medium and long-chain fatty acids. There is evidence of a link between FFAR1 (GPR40) and the ability of fatty acids to amplify glucose-stimulated insulin secretion, making this signaling pathway a potential...
Keywords: | (3S)-6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid |
Application: | FFAR1/GPR40 agonist |
CAS | 1000413-72-8 |
MW: | 524.6 D |
From 60.00€
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Item number: Cay19388-5
DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Cay-90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively. At 10 mg/kg, it has been...
Keywords: | N-(4-butylphenyl)-4-fluoro-benzenesulfonamide |
Application: | Free fatty acid receptor 1 (FFAR1/GPR40) antagonist |
CAS | 346692-04-4 |
MW: | 307.4 D |
From 62.00€
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Item number: ARG63777.100
Protein function: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a...
Keywords: | Anti-GPR40, Anti-FFAR1, Anti-Free fatty acid receptor 1, Anti-G-protein coupled receptor 40 |
Application: | ELISA, WB |
Host: | Goat |
Species reactivity: | human |
784.00€
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Item number: Cay22131-1
TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells). It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a...
Keywords: | 4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluoro-benzenepropanoic acid |
Application: | GPR40 agonist |
CAS | 1402601-82-4 |
MW: | 307.3 D |
From 50.00€
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Item number: Cay10007205-1
GPR40 is a seven transmembrane G Protein-coupled receptor with signalling mediated by medium- and long-chain fatty acids. Found predominantly in the beta-cells of pancreatic islets, it has been implicated in the regulation of insulin secretion. Overexpression of GPR40 in mouse beta cells leads to glucose intolerance...
Keywords: | Anti-FFAR1, Anti-GPR40, Anti-Free fatty acid receptor 1, Anti-Free fatty acid receptor 1, Anti-G-protein coupled receptor... |
Application: | IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
422.00€
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Item number: LKT-P3198.25
Fatty acid metabolite of chlorophyll, RXR and PPAR agonist, potential GPR40 agonist.
Keywords: | 3,7,11,15-Tetramethylhexadecanoic acid |
Application: | Fatty acid metabolite of chlorophyll, RXR and PPAR agonist, potential GPR40 agonist |
CAS | 14721-66-5 |
MW: | 312.53 D |
From 357.00€
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