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Tissue transglutaminase (TGM2) post-translationally modifies proteins by catalyzing intermolecular cross-linkages between glutamine and lysine side chains. TGM2 has roles in neurodegenerative disorders, celiac sprue, cancer, and fibrotic diseases. Cystamine is an organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM. It is orally available and is neuroprotective in mouse models of Huntington's disease. Cystamine also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.Formal Name: 2,2'-dithiobis-ethanamine, dihydrochloride. CAS Number: 56-17-7. Molecular Formula: C4H12N2S2 . 2HCl. Formula Weight: 225.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: NCCSSCCN.Cl.Cl. InChi Code: InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6,,/h1-6H2,2*1H. InChi Key: YUFRRMZSSPQMOS-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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