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CX-516 is an AMPA receptor modulator. It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, CX-516 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner. It enhances performance in a spatial, delayed nonmatch-to-sample (DNMS) test in rats. CX-516 also reverses dominance between initially dominant and submissive rat pairs, a marker of antidepressant-like activity, in the rat reduction of submissive behavior model.Formal Name: 1-piperidinyl-6-quinoxalinyl-methanone. CAS Number: 154235-83-3. Synonyms: Ampalex, BDP-12, Benzoyl-Piperidine-12. Molecular Formula: C14H15N3O. Formula Weight: 241.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 203, 237, 319 nm. SMILES: O=C(C1=CC(N=CC=N2)=C2C=C1)N3CCCCC3. InChi Code: InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2. InChi Key: ANDGGVOPIJEHOF-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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