57 products were found matching "K05199"!

Description: GRIA3 Protein, Human, Recombinant (His) is expressed in Yeast. The accession number is P42263.

AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Glutamate receptor 3 (GluR3) knockout mice exhibited normal...

Tianeptine is an atypical antidepressant. It is an agonist of the µ-opioid receptor (MOR, EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system. Tianeptine (30 mg/kg) decreases immobility in the forced swim test in...

Receptors for AMPA are ionotropic glutamate receptors with critical roles in neurological development and function. Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 µM). It blocks the rapid agonist-induced...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. It is mapped to Xq25. Glutamate receptors are the predominant excitatory...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA) receptors. It is mapped to Xq25. Glutamate receptors are the predominant excitatory...

Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 µM for evoking glutamate currents in isolated pyramidal neurons. In rats, it enhances novel object recognition memory (0.1 mg/kg, p.o.) and attentional set-shifting (0.3 mg/kg, p.o.) and reverses a...

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of...

S18986 is a positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that potently enhances (S)-AMPA-mediated noradrenaline release in rat hippocampal and frontal cortex slices. S18986 is orally bioavailable and penetrates the blood-brain barrier in animals....

AMPA antagonist.

CX-516 is an AMPA receptor modulator. It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, CX-516 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner....

Talampanel is an allosteric AMPA receptor antagonist (IC50 = 2.5 µM in cerebellar Purkinje neurons using voltage-clamp electrophysiology). It reduces the firing rate of spinal neurons in rats by 68% when administered at a dose of 10 mg/kg following AMPA administration. It is protective against seizures in mouse...