Cudetaxestat

Cudetaxestat is an inhibitor of autotaxin (IC50 = =0.5 µM), also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2). It reduces migration of MDA-MB-435 melanoma cells (IC50 = 15 nM). Cudetaxestat reduces blood glucose levels in a glucose tolerance test, as well as baseline blood glucose levels, in mice fed a high-fat diet when administered at a dose of 15 mg/kg twice per day for two days. It reduces liver fibrosis in mice fed a choline-deficient, L-amino acid-defined, high-fat diet (CDAA/HFD) as a model of liver fibrosis when administered at a dose of 10 mg/kg. It also reduces colon ulcer area and increases colon length in mouse models of acute and chronic ulcerative colitis, respectively.Formal Name: 3-[[2,6-dichloro-7-fluoro-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]thio]-2-fluoro-benzoic acid. CAS Number: 1782070-21-6. Molecular Formula: C21H15Cl2F2N3O2S. Formula Weight: 482.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C(O)C1=C(F)C(SC2=C(Cl)N(C3=CN(CCC)N=C3)C4=C(F)C(Cl)=CC=C24)=CC=C1. InChi Code: InChI=1S/C21H15Cl2F2N3O2S/c1-2-8-27-10-11(9-26-27)28-18-13(6-7-14(22)17(18)25)19(20(28)23)31-15-5-3-4-12(16(15)24)21(29)30/h3-7,9-10H,2,8H2,1H3,(H,29,30). InChi Key: NMDFAQXLJQRHMS-UHFFFAOYSA-N.