CU-32

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50 = 0.45 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS (Cay-22810) over toll-like receptors (TLRs) at 50 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-beta in THP-1 cells when used at concentrations of 10, 30, and 100 µM.Formal Name: methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate. CAS Number: 2400954-16-5. Molecular Formula: C11H10IN5O2. Formula Weight: 371.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 265 nm. SMILES: IC1=CC=C(NC2=NC(N)=NC(C(OC)=O)=N2)C=C1. InChi Code: InChI=1S/C11H10IN5O2/c1-19-9(18)8-15-10(13)17-11(16-8)14-7-4-2-6(12)3-5-7/h2-5H,1H3,(H3,13,14,15,16,17). InChi Key: QVIGCTKZZBSSBW-UHFFFAOYSA-N.