58 products were found matching "K17834"!

An SM-102-based LNP solution for expressing naked mole-rat cGAS, composed of SM-102, cholesterol, 1,2-DSPC, and DMG-PEG(2000) at a molar ratio of 50:38.5:10:1.5 and encapsulating mRNA encoding His-tagged naked mole-rat cGAS, intended for the overexpression of His-tagged naked mole-rat cGAS in vitro and can be used...

An SM-102-based LNP solution for expressing human cGAS, composed of SM-102, cholesterol, 1,2-DSPC, and DMG-PEG(2000) at a molar ratio of 50:38.5:10:1.5 and encapsulating mRNA encoding His-tagged human cGAS, intended for the overexpression of His-tagged human wild-type cGAS in vitro and can be used in a variety of...

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which...

2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79...

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 0.24 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases...

Cayman's cGAS Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human cGAS, which is a cytosolic dsDNA sensor that detects microbial pathogens. The assay directly measures 2'3'-cGAMP produced by cGAS in the presence of DNA, ATP, and GTP. The cyclic...

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50 = 0.45 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also...

RU-521 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50 = 0.11 µM). It inhibits dsDNA-, but not IFN-beta- or 5'ppp-HP20 RNA-, induced IFN-beta1-dependent gene expression in reporter assays and does not inhibit Pam3CSK4-, poly(I:C)-, or LPS-induced Il6 mRNA expression in RAW 264.7 cells, indicating...

PF-06928215 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 4.9 µM in a fluorescence polarization assay).Formal Name: (1R,2S)-2-[[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)carbonyl]amino]-cyclohexanecarboxylic acid. CAS Number: 2378173-15-8. Molecular Formula: C20H20N4O4. Formula Weight: 380.4....

G150 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 10.2 nM for the human enzyme). It is selective for human cGAS over mouse cGAS (IC50 = 25,000 nM). G150 inhibits dsDNA-induced expression of IFNB1 in THP-1 cells and isolated human monocyte-derived macrophages (IC50s = 1.96 and 0.62 µM, respectively) but...

Description: RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS. Target: DNA, cGAS. Smiles: Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1. References: Vincent J, et al. Small molecule inhibition of cGAS reduces interferon...

Cyclic GMP-AMP (cGAMP) synthase (cGAS, Cay-22810) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP,...