Cordycepin

Cordycepin is a nucleoside analog originally isolated from C. militaris that has diverse biological activities. Upon entry into cells, it is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis. It incorporates into DNA and RNA at internal and terminal positions in SK-HEP-1 cells. Cordycepin (0.1-1 mg/ml) is active against B. subtilis. It increases IL-10 secretion and mRNA expression in isolated human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 24 µg/ml. Cordycepin (1 mg/kg per day) increases survival of mice infected with C. albicans or C. krusei.Formal Name: 3'-deoxy-adenosine. CAS Number: 73-03-0. Synonyms: 3'-Deoxyadenosine, NSC 63984, NSC 401022. Molecular Formula: C10H13N5O3. Formula Weight: 251.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 210, 260 nm. SMILES: OC[C@@H]1C[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1. InChi Code: InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1. InChi Key: OFEZSBMBBKLLBJ-BAJZRUMYSA-N. Origin: Fungus/Cordyceps militaris.