Clomiphene (citrate)

Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17beta-estradiol. It potently binds both ERalpha and ERbeta (Ki = 0.9 and 1.2 nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.Formal Name: 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-ethanamine, 2-hydroxy-1,2,3-propanetricarboxylate. CAS Number: 50-41-9. Synonyms: Clomifene, Omifin, NSC 35770. Molecular Formula: C26H28ClNO . C6H8O7. Formula Weight: 598.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 205, 236, 294 nm. SMILES: Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)\C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O. InChi Code: InChI=1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23,7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3,13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-,. InChi Key: PYTMYKVIJXPNBD-OQKDUQJOSA-N.