Cl-Amidine (trifluoroacetate salt)

Cl-Amidine (trifluoroacetate salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10599-1 1 mg -

1 - 10 business days

44.00€
Cay10599-5 5 mg -

1 - 10 business days

175.00€
Cay10599-10 10 mg -

1 - 10 business days

242.00€
 
Cl-amidine is an inhibitor of protein arginine deiminases (PAD, IC50s = 0.8, 6.2, and 5.9 µM for... more
Product information "Cl-Amidine (trifluoroacetate salt)"
Cl-amidine is an inhibitor of protein arginine deiminases (PAD, IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4 in vitro, respectively). It irreversibly inactivates all four PAD subtypes (kinact/KI = 37,000, 1,200, 2,000, and 13,000 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity. Cl-amidine is cytotoxic to HL-60, MCF7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05 and 1 µM, respectively). In a collagen-induced mouse model of inflammatory arthritis, Cl-amidine dose-dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.
Keywords: N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide 2,2,2-trifluoroacetate
Supplier: Cayman Chemical
Supplier-Nr: 10599-1

Properties

Application: Peptidyl arginine deiminase (PAD) inhibitor
MW: 424.8 D
Formula: C14H19ClN4O2 . CF3CO2H
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 1043444-18-3| Search using CAS
KEGG ID : K01481 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
GHS Hazard Pictograms:
H Phrases: H225, H301, H311, H331, H370
Caution
Our products are for laboratory research use only: Not for administration to humans!
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