CK7

CK7 is an inhibitor of cyclin-dependent kinase 2 (Cdk2) and Cdk9 (Kis = 2 and 4 nM, respectively). It is selective for Cdk2 and Cdk9 over Cdk1, Cdk4, and Cdk7 (Kis = 80, 53, and 70 nM, respectively), as well as 10 additional kinases (Kis = >1,000 nM for all). CK7 is cytotoxic to A2780 ovarian and MES-SA uterine cancer cells (IC50s = 41 and 140 nM, respectively).Formal Name: 4-(2-amino-4-methyl-5-thiazolyl)-N-(3-nitrophenyl)-2-pyrimidinamine. CAS Number: 507487-89-0. Synonyms: Cdk2/9 Inhibitor, Cyclin-dependent kinase 2/9 Inhibitor. Molecular Formula: C14H12N6O2S. Formula Weight: 328.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, Methanol: Slightly soluble. SMILES: CC1=C(C2=NC(NC3=CC([N+]([O-])=O)=CC=C3)=NC=C2)SC(N)=N1. InChi Code: InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19). InChi Key: DYTKVFHLKPDNRW-UHFFFAOYSA-N.