Cilazaprilat

Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 0.7 nM for the rat enzyme) and an active metabolite of cilazapril (Cay-29777). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 µM. Intra-arterial administration of cilazaprilat (3 µg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.Formal Name: (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid. CAS Number: 90139-06-3. Synonyms: Ro 31-3113. Molecular Formula: C20H27N3O5. Formula Weight: 389.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: aqueous base: Slightly soluble, DMSO: Slightly soluble. SMILES: OC([C@H]1N(C2=O)N(CCC[C@@H]2N[C@H](C(O)=O)CCC3=CC=CC=C3)CCC1)=O. InChi Code: InChI=1S/C20H27N3O5/c24-18-15(8-4-12-22-13-5-9-17(20(27)28)23(18)22)21-16(19(25)26)11-10-14-6-2-1-3-7-14/h1-3,6-7,15-17,21H,4-5,8-13H2,(H,25,26)(H,27,28)/t15-,16-,17-/m0/s1. InChi Key: UVAUYSRYXACKSC-ULQDDVLXSA-N.