CGS 21680 (hydrochloride)

CGS 21680 is a potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM). It is less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM). CGS 21680 is commonly used to study the actions of the adenosine A2A receptor in cells and tissues.Formal Name: 4-[2-[[6-amino-9-(N-ethyl-beta-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]-benzenepropanoic acid, monohydrochloride. CAS Number: 124431-80-7. Molecular Formula: C23H29N7O6 . HCl. Formula Weight: 536.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 210, 218, 252, 292 nm. SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(NCCC4=CC=C(CCC(O)=O)C=C4)N=C3N)O[C@@H]1C(NCC)=O.Cl. InChi Code: InChI=1S/C23H29N7O6.ClH/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32,/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29),1H/t16-,17+,18-,22+,/m0./s1. InChi Key: QPHVMNOEKKJYJO-MJWSIIAUSA-N.