104 products were found matching "K04266"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. ADORA2A antibody recognizes Adenosine receptor A2A, a G protein-coupled receptor (GPCR) that mediates adenosine signaling to regulate neurotransmission, vascular tone, and immune responses. The ADORA2A gene, located on chromosome 22q11.23,...

Recombinant CHO-K1 cells stably overexpress human adenosine A2A receptor (ADORA2A) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

Recombinant CHO-K1 cells stably overexpress Mus musculus adenosine A2A receptor (ADORA2A) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

ANR 94 is an adenosine A2A receptor antagonist (Ki = 0.046 µM). It is selective for the adenosine A2A receptor over adenosine A1, -A2B, and -A3 receptors (Kis = 2.4, >30, and 21 µM, respectively). ANR 94 (5 mg/kg) reduces the number of parkinsonian-like tremors induced by tacrine (Cay70240) in rats. It decreases...

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 µM for A1, A2A, A2B, and A3, respectively). At higher...

ZM 241385 is a potent antagonist of A2A adenosine receptors (pIC50 = 9.52 for displacement of 5'-N-ethylcarboxamidoadenosine from rat phaeochromocytoma cell membranes). It displays little or no activity at other A adenosine receptors. ZM 241385 is active in vivo. It acts as an inverse agonist at constitutively...

CGS 21680 is a potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM). It is less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM). CGS 21680 is commonly used to study the actions of the adenosine A2A receptor...

Adenosine is a purine nucleoside composed of adenine and ribose linked by a glycosidic linkage. It is an endogenous ligand of a family of four adenosine receptors, which serve diverse roles related to smooth muscle tone, central nervous system regulation, and cardiac function. Adenosine is a precursor for adenosine...

SCH 58261 is a competitive antagonist of the adenosine A2A receptor (Kis = 2.3 and 2.0 nM in rat and bovine brain, respectively). It is selective for the A2A subtype, displaying an A1/A2A selectivity ratio of 50-100-fold and does not interact with A2B or A3 receptors. SCH 58261 has been used to improve 6-hydroxy...

Xanthine amine congener (XAC) is a non-selective adenosine receptor antagonist with Kb values of 83, 25, and 15 nM for rat PC12 cells, human platelets that endogenously express adenosine A2A receptors, and rat fat cells that endogenously express A1 receptors, respectively. It reduces adenylate cyclase activity...

5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride (Cay-14409) with diverse biological activities. It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 µM, as...

AB-928 is an adenosine A2A and A2B receptor dual antagonist. It inhibits the ability of adenosine (Cay-21232) to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro. AB-928, alone or in combination with doxorubicin (Cay-15007), reduces tumor growth in an AT3-OVA...