CGP 35348

The amino acid gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. CGP 35348 is a selective, brain-accessible GABAB receptor antagonist (IC50 = 34 µM). It blocks the action of the GABAB-selective agonist baclofen (Cay-18600) at postsynaptic sites but not at presynaptic receptors. CGP 35348 prevents baclofen-induced antinociception and muscle relaxation in mice and rats. It is commonly used to investigate the role of GABAB activation in neurological signaling.Formal Name: P-(3-aminopropyl)-P-(diethoxymethyl)-phosphinic acid. CAS Number: 123690-79-9. Molecular Formula: C8H20NO4P. Formula Weight: 225.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 0.1 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CCOC(OCC)P(CCCN)(O)=O. InChi Code: InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11). InChi Key: QIIVUOWTHWIXFO-UHFFFAOYSA-N.