Centhaquin

Centhaquin is a resuscitative agent. It binds to serotonin (5-HT) receptors in isolated rat cerebral cortex and brainstem membranes (Kis = 178.9 and 103.7 nM, respectively). Centhaquin (0.05-0.45 mg/kg) increases the latency to tail-flick in mice, an effect that can be reversed by the alpha2A-adenergic receptor (alpha2A-AR) antagonist BRL 44408 (Cay-29454) and alpha2B-AR antagonist imiloxan but not the alpha2C-AR antagonist JP-1302 (Cay-25974). It increases mean arterial blood pressure (MAP), cardiac output, and survival following bleeding-induced hypotension in a rat model of hemorrhagic shock when administered at doses ranging from 0.006 to 0.05 mg/kg in combination with hypertonic saline.Formal Name: 2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]-quinoline. CAS Number: 57961-90-7. Synonyms: Centhaquine, PMZ-2010. Molecular Formula: C22H25N3. Formula Weight: 331.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml. lambdamax: 227 nm. SMILES: CC1=CC(N(CC2)CCN2CCC3=NC4=C(C=C3)C=CC=C4)=CC=C1. InChi Code: InChI=1S/C22H25N3/c1-18-5-4-7-21(17-18)25-15-13-24(14-16-25)12-11-20-10-9-19-6-2-3-8-22(19)23-20/h2-10,17H,11-16H2,1H3. InChi Key: UJNWGFBJUHIJKK-UHFFFAOYSA-N.