63 products were found matching "K04139"!

Dexmedetomidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs). It selectively binds to alpha2-ARs over alpha1-ARs (Kis = 0.015 and 5 nM, respectively). In vivo, dexmedetomidine (50 µg/kg) prevents increases in cardiac troponin I (CTnI), a marker of myocardial injury, as well as reduces myocardial...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from...

Xylazine is an agonist of alpha2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an alpha2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard...

Xylazine is an agonist of alpha2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an alpha2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard...

Centhaquin is a resuscitative agent. It binds to serotonin (5-HT) receptors in isolated rat cerebral cortex and brainstem membranes (Kis = 178.9 and 103.7 nM, respectively). Centhaquin (0.05-0.45 mg/kg) increases the latency to tail-flick in mice, an effect that can be reversed by the alpha2A-adenergic receptor...

Detomidine (hydrochloride) (Cay-38583) is an analytical reference standard categorized as a sedative. Detomidine has sedative activity in horses. Formulations containing detomidine have been used as veterinary sedatives. This product is intended for analytical forensic applications. This product is also available as...

Medetomidine (hydrochloride) (CRM) (Cay-38807) is a certified reference material categorized as a sedative. Medetomidine induces sedation in dogs. It has analgesic activity alone, and an additive analgesic effect in combination with fentanyl (Cay-ISO60197, Cay-14719, Cay-23580) or morphine (Cay-ISO60147, Cay-15464),...

Tizanidine (hydrochloride) (Cay-38559) is an analytical reference standard categorized as a muscle relaxant. Tizanidine inhibits alpha- and gamma-rigidity in rats, reflex muscle tone in rabbits, and the linguomandibular reflex in cats. It has been associated with fatal overdoses. Formulations containing tizanidine...

Romifidine (hydrochloride) (Cay-38581) is an analytical reference standard categorized as a sedative and analgesic. Romifidine has antinociceptive and sedative activities in donkeys. Formulations containing romifidine have been used as veterinary sedatives. This product is intended for research and forensic...

TDIQ (hydrochloride) is an analytical reference standard that is classified as a phenylalkylamine. It is related in structure to amphetamines but does not appear to affect locomotor activity. TDIQ is a partial agonist of alpha2A-, alpha2B-, and alpha2C-adrenergic receptors (Kis = 75, 95, and 65 nM, respectively) but...

Xylazine (Cay-22641) is an analytical reference standard categorized as an anesthetic. It has been used as an adulterant in drugs of abuse and misused, leading to non-fatal and fatal intoxications. This product is intended for use in analytical forensic applications. This product is also available as a general...

Levonordefrin is the (-)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Cay-16673), that acts as a vasoconstrictor. Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer. It...