CB-13

CB-13 is a dual agonist of the CB1 (IC50 = 15 nM) and CB2 (IC50 = 98 nM) receptors. In rats, oral CB-13 (3 mg/kg) potently blocks CB1-dependent neuropathic mechanical hyperalgesia, shows limited brain penetration, and exhibits good oral bioavailability. CB-13 does not possess genotoxic potential, as indicated by negative results in both chromosome aberration and reverse mutation assays. The effects of CB-13 on other aspects of CB signaling have not been assessed.Formal Name: 1-naphthalenyl[4-(pentylox)-1-naphthalenyl]-methanone. CAS Number: 432047-72-8. Synonyms: CRA-13. Molecular Formula: C26H24O2. Formula Weight: 368.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.2 mg/ml, Methanol: 1 mg/ml. lambdamax: 220, 333 nm. SMILES: CCCCCOc1ccc(c2ccccc12)C(=O)c1cccc2ccccc12. InChi Code: InChI=1S/C26H24O2/c1-2-3-8-18-28-25-17-16-24(21-13-6-7-14-22(21)25)26(27)23-15-9-11-19-10-4-5-12-20(19)23/h4-7,9-17H,2-3,8,18H2,1H3. InChi Key: RSUMDJRTAFBISX-UHFFFAOYSA-N.