CAY10640

Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.Formal Name: N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea. CAS Number: 1208549-68-1. Synonyms: sEHi, Soluble Epoxide Hydrolase Inhibitor. Molecular Formula: C17H20F3N3O3. Formula Weight: 371.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): Isoluble. lambdamax: 241, 278 nm. SMILES: O=C(NC1CCN(C(C2CC2)=O)CC1)NC3=CC=C(OC(F)(F)F)C=C3. InChi Code: InChI=1S/C17H20F3N3O3/c18-17(19,20)26-14-5-3-12(4-6-14)21-16(25)22-13-7-9-23(10-8-13)15(24)11-1-2-11/h3-6,11,13H,1-2,7-10H2,(H2,21,22,25). InChi Key: CHOHWMGAQRIMFF-UHFFFAOYSA-N.