CAY10508

Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM. A 10 µM concentration of CAY10508 resulted in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and peripheral cannabinoid (CB2) receptors, respectively. A [35S]-GTPgammaS binding assay revealed the inverse agonist properties of CAY10508 at the CB1 receptor.Formal Name: 1,3-bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione. CAS Number: 878533-35-8. Molecular Formula: C21H14Br2N2O2. Formula Weight: 486.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): .25 mg/ml, DMSO: 10 mg/ml. lambdamax: 248 nm. SMILES: Brc1ccc(cc1)N1C(=O)C(c2ccccc2)N(c2ccc(Br)cc2)C1=O. InChi Code: InChI=1S/C21H14Br2N2O2/c22-15-6-10-17(11-7-15)24-19(14-4-2-1-3-5-14)20(26)25(21(24)27)18-12-8-16(23)9-13-18/h1-13,19H. InChi Key: ROASQEPZAKGACK-UHFFFAOYSA-N.