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Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM. A 10 µM concentration of CAY10508 resulted in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and peripheral cannabinoid (CB2) receptors, respectively. A [35S]-GTPgammaS binding assay revealed the inverse agonist properties of CAY10508 at the CB1 receptor.Formal Name: 1,3-bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione. CAS Number: 878533-35-8. Molecular Formula: C21H14Br2N2O2. Formula Weight: 486.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:2): .25 mg/ml, DMSO: 10 mg/ml. lambdamax: 248 nm. SMILES: Brc1ccc(cc1)N1C(=O)C(c2ccccc2)N(c2ccc(Br)cc2)C1=O. InChi Code: InChI=1S/C21H14Br2N2O2/c22-15-6-10-17(11-7-15)24-19(14-4-2-1-3-5-14)20(26)25(21(24)27)18-12-8-16(23)9-13-18/h1-13,19H. InChi Key: ROASQEPZAKGACK-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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