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Phosphoinositide 3-kinase gamma (PI3Kgamma), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the gamma isoform (IC50 = 30 nM) better than the alpha, beta, and delta isoforms (IC50 = 0.94, 20, and 20 µM, respectively). Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM). Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kgamma-deficient mice.Formal Name: 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione. CAS Number: 328960-84-5. Molecular Formula: C14H8FNO3S. Formula Weight: 289.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml. lambdamax: 238, 270, 389 nm. SMILES: Fc1ccc(cc1)c1ccc(/C=C2\SC(=O)NC/2=O)o1. InChi Code: InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+. InChi Key: UFBTYTGRUBUUIL-KPKJPENVSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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