CAY10505

Phosphoinositide 3-kinase gamma (PI3Kgamma), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the gamma isoform (IC50 = 30 nM) better than the alpha, beta, and delta isoforms (IC50 = 0.94, 20, and 20 µM, respectively). Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM). Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kgamma-deficient mice.Formal Name: 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione. CAS Number: 328960-84-5. Molecular Formula: C14H8FNO3S. Formula Weight: 289.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml. lambdamax: 238, 270, 389 nm. SMILES: Fc1ccc(cc1)c1ccc(/C=C2\SC(=O)NC/2=O)o1. InChi Code: InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+. InChi Key: UFBTYTGRUBUUIL-KPKJPENVSA-N.