CAY10465

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. CAY10465 is an analog of resveratrol acting as a potent and selective AhR agonist, with a Ki of 0.2 nM. CAY10465 is inactive as a ligand for the estrogen receptor even at 100 µM.Formal Name: 1,3-dichloro-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-benzene. CAS Number: 688348-33-6. Molecular Formula: C15H9Cl2F3. Formula Weight: 317.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:1): .5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 211, 229, 245, 298, 309 nm. SMILES: Clc1cc(/C=C\c2ccc(cc2)C(F)(F)F)cc(Cl)c1. InChi Code: InChI=1S/C15H9Cl2F3/c16-13-7-11(8-14(17)9-13)2-1-10-3-5-12(6-4-10)15(18,19)20/h1-9H/b2-1+. InChi Key: ISPYNXGXZRLLHM-OWOJBTEDSA-N.