132 products were found matching "K09093"!

L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR, Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in...

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. alpha-Naphthoflavone is a flavone that modulates xenobiotic metabolism at...

Extending the pluripotency of hematopoietic stem cells (HSC) is of key importance to the application of stem cell therapies in a variety of diseases. Loss of the expression of the cell surface proteins CD34 and CD133 is one marker of HSC differentiation and thus often monitored in assays to test potential compounds...

6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR, Kd = 70 pM). This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively)....

L-Kynurenine-d4 is intended for use as an internal standard for the quantification of kynurenine by GC- or LC-MS. L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to...

2,3,7,8-Tetrachlorodibenzo-p-dioxin is a toxicant and an agonist of the aryl hydrocarbon receptor (AhR, ED50 = 0.2 nmol/kg in a reporter assay using chicken embryos). It also induces AhR ubiquitination and degradation in Hepa-1c1c7 hepatic cells when used at a concentration of 1 nM. Oral administration of...

Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein (Cay-10005166). It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 µM. Formononetin has been reported to possess antitumor and antiviral activity.Formal Name:...

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that up-regulates many xenobiotic metabolizing enzymes, particularly in response to planar aromatic hydrocarbons. CH 223191 is a potent and specific antagonist of AhR that blocks activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD,...

Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4'-methyl genistein, biochanin A can be metabolized in vivo...

INDIGO's Aryl Hydrocarbon Receptor (AhR) Reporter Cells include the luciferase reporter gene functionally linked to an AhR-responsive promoter. Thus, quantifying changes in luciferase expression in the treated reporter cells provides a sensitive surrogate measure of the changes in AhR activity. The principle...

Galangin is a flavonoid naturally found in herbs used in traditional medicine. Like many flavonoids, it has potent antioxidant properties. It also has anti-inflammatory actions related to suppression of signaling through NF-kappaB in mice. Galangin acts as an antagonist of the aryl hydrocarbon receptor, inducing...

beta-Naphthoflavone is a non-carcinogenic agonist of the aryl hydrocarbon receptor (AhR). It activates transcription of the AhR target gene CYP1A1 when used at concentrations of 1 and 10 µM in HepG2 cells. beta-Naphthoflavone (10 µM) inhibits hydrogen peroxide-induced apoptosis, as well as increases the activity of...