135 products were found matching "K09093"!

Protein function: Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467,...

Protein function: Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467,...

GNF351 is a potent AhR (aryl hydrocarbon receptor) antagonist. Aryl hydrocarbon receptor (AhR) is a ligand-dependent nuclear receptor that functions as a transcription factor. It can follow a canonical signaling pathway where binding of ligands to the cytosolic AhR induces the formation of a complex that...

FICZ is a potent AhR (aryl hydrocarbon receptor) agonist. Aryl hydrocarbon receptor (AhR) is a ligand-dependent nuclear receptor that functions as a transcription factor. It can follow a canonical signaling pathway where binding of ligands to the cytosolic AhR induces the formation of a complex that translocates to...

Tapinarof, also known as WBI-1001, is a natural AhR (aryl hydrocarbon receptor) agonist. Aryl hydrocarbon receptor (AhR) is a ligand-dependent nuclear receptor that functions as a transcription factor. It can follow a canonical signaling pathway where binding of ligands to the cytosolic AhR induces the formation of...

MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist. Aryl hydrocarbon receptor (AhR) is a ligand-dependent nuclear receptor that functions as a transcription factor. It can follow a canonical signaling pathway where binding of ligands to the cytosolic AhR induces the formation of a complex that translocates to...

L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR, Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in...

2,3,7,8-Tetrachlorodibenzo-p-dioxin is a toxicant and an agonist of the aryl hydrocarbon receptor (AhR, ED50 = 0.2 nmol/kg in a reporter assay using chicken embryos). It also induces AhR ubiquitination and degradation in Hepa-1c1c7 hepatic cells when used at a concentration of 1 nM. Oral administration of...

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. alpha-Naphthoflavone is a flavone that modulates xenobiotic metabolism at...

Extending the pluripotency of hematopoietic stem cells (HSC) is of key importance to the application of stem cell therapies in a variety of diseases. Loss of the expression of the cell surface proteins CD34 and CD133 is one marker of HSC differentiation and thus often monitored in assays to test potential compounds...

L-Kynurenine-d4 is intended for use as an internal standard for the quantification of kynurenine by GC- or LC-MS. L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to...

6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR, Kd = 70 pM). This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively)....