CAY10464

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar. CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations. It is inactive as an estrogen receptor ligands even at 100 µM.Formal Name: 1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene. CAS Number: 688348-37-0. Molecular Formula: C15H12Cl2O. Formula Weight: 279.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:1): .5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 212, 326 nm. SMILES: COc1ccc(cc1)\C=C/c1cc(Cl)cc(Cl)c1. InChi Code: InChI=1S/C15H12Cl2O/c1-18-15-6-4-11(5-7-15)2-3-12-8-13(16)10-14(17)9-12/h2-10H,1H3/b3-2+. InChi Key: YDVZIQMQLZBUKX-NSCUHMNNSA-N.