CAY10398

CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 µM. Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA. However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC.Formal Name: 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide. CAS Number: 193551-00-7. Synonyms: MD 85, PX 089274. Molecular Formula: C15H23N3O3. Formula Weight: 293.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 300 µg/ml, DMSO: 14 mg/ml, Ethanol: 1 mg/ml. lambdamax: 301 nm. SMILES: ONC(=O)CCCCCNC(=O)c1ccc(cc1)N(C)C. InChi Code: InChI=1S/C15H23N3O3/c1-18(2)13-9-7-12(8-10-13)15(20)16-11-5-3-4-6-14(19)17-21/h7-10,21H,3-6,11H2,1-2H3,(H,16,20)(H,17,19). InChi Key: RGWSSTALGUXZMU-UHFFFAOYSA-N.