BX-517

BX-517 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1, IC50 = 6 nM). It binds to the ATP binding pocket of PDK1, inhibits Akt2 activation induced by PDK1 in a cell-free assay (IC50 = 20 nM), and inhibits Akt phosphorylation in PC3 cells.Formal Name: N-[2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-urea. CAS Number: 850717-64-5. Synonyms: PDK1 Inhibitor II. Molecular Formula: C15H14N4O2. Formula Weight: 282.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: Partially soluble. lambdamax: 221, 279, 297, 308, 396 nm. SMILES: O=C1/C(C2=CC(NC(N)=O)=CC=C2N1)=C(C3=CC=CN3)/C. InChi Code: InChI=1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-. InChi Key: DFURSNCTQGJRRX-JYRVWZFOSA-N.