BTS-54-505 (hydrochloride)

BTS-54-505 is an active metabolite of sibutramine. It inhibits norepinephrine, serotonin (5-HT), and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively). In vivo, BTS-54-505 prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg) and decreases immobility in the Porsolt learned helplessness test in mice when administered at a dose of 10 mg/kg. BTS-54-505 (10 mg/kg) increases colonic temperature, a marker of thermogenesis, and decreases food intake in rats.Formal Name: 1-(4-chlorophenyl)-alpha-(2-methylpropyl)-cyclobutanemethanamine, monohydrochloride. CAS Number: 84484-78-6. Molecular Formula: C15H22ClN . HCl. Formula Weight: 288.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Water: Soluble. SMILES: NC(CC(C)C)C1(C2=CC=C(Cl)C=C2)CCC1.Cl. InChi Code: InChI=1S/C15H22ClN.ClH/c1-11(2)10-14(17)15(8-3-9-15)12-4-6-13(16)7-5-12,/h4-7,11,14H,3,8-10,17H2,1-2H3,1H. InChi Key: KHRVYINTXCWNRF-UHFFFAOYSA-N.