60 products were found matching "K05036"!

GBR 12783 is a dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes). It is selective for inhibition of dopamine uptake over norepinephrine or serotonin (5-HT) uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively). GBR 12783 (10 mg/kg, i.p.) improves learning...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DAT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DAT. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse DAT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse DAT. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat DAT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat DAT. Next, Avidin...

BTS-54-505 is an active metabolite of sibutramine. It inhibits norepinephrine, serotonin (5-HT), and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively). In vivo, BTS-54-505 prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg) and decreases immobility in the Porsolt...

Benztropine is an inhibitor of the dopamine transporter (DAT), it potentiates dopamine overflow in rat brain slices.

GBR 13069 is a dopamine uptake inhibitor. It selectively inhibits dopamine uptake over norepinephrine uptake in rat occipital cortex slices (IC50s = 40 and 800 nM, respectively). GBR 13069 (2.5, 5, and 10 mg/kg) induces ipsilateral rotation and increases locomotion in rats. It also prevents 2'-CH3-MPTP-induced...

Modafinil (Cay-15417) is an analytical reference standard that is classified as a nootropic. It is a wake-promoting agent that binds competitively and selectively to the dopamine transporter, modulating catecholaminergic signaling by inhibiting its activity (IC50 = 3 µM, Ki = 2 µM). With much weaker potency,...

N-methyl-4,4-difluoro Modafinil (Cay-18332) is an analytical reference material that is categorized as a nootropic. It is a substituted form of modafinil (Cay-15417), a wake-promoting agent that binds the dopamine transporter and modulates catecholaminergic signaling (IC50 = 3 µM, Ki = 2 µM). The physiological and...

Sibutramine (hydrochloride) (Cay-14476) is an analytical reference standard categorized as a phenylethylamine. It inhibits reuptake of serotonin (Cay-14332) and norepinephrine (Cay-16673) via the respective transporters. Sibutramine can be detected in plasma and urine. Formulations containing sibutramine were...

(±)-threo-3,4-Dichloromethylphenidate (hydrochloride) (Cay-18588) is an analytical reference material that is structurally categorized as an amphetamine. Its threo-diastereomer, 3,4-CTMP, can inhibit dopamine uptake through the dopamine transporter with an IC50 value of 65 nM in rat striatal tissue. This product is...

S,S-hydroxy Bupropion is an active metabolite of the antidepressant bupropion. It is formed from bupropion by the cytochrome P450 (CYP) isoform CYP2B6. S,S-hydroxy Bupropion inhibits dopamine and norepinephrine but not serotonin (5-HT) reuptake in HEK293 cells expressing the human transporters (IC50s = 0.63, 0.241,...