Bryostatin 1

Bryostatin 1 is a marine macrolide that has been found in B. neritina and has diverse biological activities.,,,, It binds to PKCalpha, PKCbeta1, PKCgamma, PKCdelta, PKCepsilon, PKCeta, and PKCtheta (Kis = 0.8-3.0 nM) and induces PKC activation or inhibition in cancer cells in a concentration-dependent manner., Bryostatin 1 (50 nM) reduces the production of IL-2 and increases the production of IL-10 in LPS-stimulated mouse bone marrow-derived dendritic cells (BMDCs). It decreases cell surface levels of CD4 and chemokine (C-C motif) receptor 5 (CCR5) and reduces HIV-1 infectivity in isolated human monocyte-derived macrophages. In vivo, bryostatin 1 (30 µg/kg) reduces spinal cord and brain T cell infiltration and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE). It also decreases blast-induced increases in blood-brain barrier (BBB) permeability in a rat model of traumatic brain injury (TBI) when administered at a dose of 2.5 mg/kg.Formal Name: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E,4E)-2,4-octadienoic acid ester. CAS Number: 83314-01-6. Synonyms: NSC 339555. Molecular Formula: C47H68O17. Formula Weight: 905.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. SMILES: O[C@](O[C@@](C[C@](OC(C[C@@H](C[C@@](C1)([H])O2)O)=O)([H])[C@H](O)C)([H])C/C3=C\C(OC)=O)(C(C)(/C=C/[C@](C/C4=C\C(OC)=O)([H])O[C@](C4)([H])C[C@]2(C(C)([C@H]1OC(C)=O)C)O)C)[C@H]3OC(/C=C/C=C/CCC)=O. InChi Code: InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1. InChi Key: MJQUEDHRCUIRLF-TVIXENOKSA-N. Origin: Animal/Bugula neritina.