BRD4884

BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min versus 20 min). BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration.Formal Name: N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)tetrahydro-2H-pyran-4-carboxamide. CAS Number: 1404559-91-6. Molecular Formula: C18H19FN2O2. Formula Weight: 314.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 211, 276 nm. SMILES: FC1=CC=C(C2=CC=C(N)C(NC(C3CCOCC3)=O)=C2)C=C1. InChi Code: InChI=1S/C18H19FN2O2/c19-15-4-1-12(2-5-15)14-3-6-16(20)17(11-14)21-18(22)13-7-9-23-10-8-13/h1-6,11,13H,7-10,20H2,(H,21,22). InChi Key: ZFCDNONWGMYBHA-UHFFFAOYSA-N.