BMS 195614

BMS 195614 is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.Formal Name: 4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-benzoic acid. CAS Number: 182135-66-6. Synonyms: BMS 614. Molecular Formula: C29H24N2O3. Formula Weight: 448.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 211, 236, 282 nm. SMILES: CC1(C)C2=CC=C(C(NC3=CC=C(C(O)=O)C=C3)=O)C=C2C(C4=CC(C=CC=C5)=C5N=C4)=CC1. InChi Code: InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34). InChi Key: WGLMBRZXZDAQHP-UHFFFAOYSA-N.