86 products were found matching "K08527"!

9-cis-Retinoic acid is a natural metabolite of vitamin A, derived from the intermediate all-trans retinoic acid (Cay-11017). It potently activates all isoforms of retinoic acid receptor (RAR) (Ki = 0.5-27 nM) as well as retinoid X receptor (RXR) isoforms (Ki = 3.8-12 nM). RAR heterodimerizes with RXR, while RXR can...

TTNPB is an analog of retinoic acid (Cay-11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARalpha, RARbeta, and RARgamma, respectively). It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM). TTNPB is used to study RAR...

AM580 is a retinoic acid receptor agonist that is selective for RARalpha (Kd = 8 nM, AC50 = 0.36 nM) compared to RARbeta (Kd = 131 nM, AC50 = 24.6 nM) and RARgamma (Kd = 450 nM, AC50 = 27.9 nM). It demonstrates greater specific binding to RARalpha compared to retinoic acid (Cay-11017), which exhibits little...

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or...

4-oxo Isotretinoin is an active metabolite of the retinoid isotretinoin (Cay-21648). It is formed from isotretinoin by several cytochrome P450 (CYP450) isoforms, including CYP3A, CYP2B6, and CYP2C19. 4-oxo Isotretinoin (10 µM) increases protein expression of cytokeratin 7 (CK7) and CK19 in normal human epidermal...

2x10(6) cells. The RARalpha Reporter (Luc)-HEK293 Cell Line is designed for monitoring the activity of retinoic acid receptor alpha (RARalpha). The RARalpha Reporter (Luc)-HEK293 Cell Line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARalpha. INDIGO's reporter cells include the luciferase...

all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid (Cay-11017) by GC- or LC-MS. all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and...

BMS 195614 is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.Formal Name:...

Ch 55 is a synthetic analog of retinoic acid (Cay-11017) that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki = 540 µM). Ch 55 has been shown to inhibit squamous cell differentiation of rabbit...

BMS 753 is a synthetic retinoid and retinoic acid receptor alpha (RARalpha) agonist (Ki = 2 nM). It is selective for RARalpha over RARgamma at 1 µM. BMS 753 (10 and 100 nM) induces morphological differentiation of P19 embryonal carcinoma cells, as well as F9 embryonal carcinoma cells when used at a concentration of...

Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARbeta and an antagonist of RARalpha and RARgamma. It has been shown to inhibit the proliferation of normal breast cells via the...