Bazedoxifene (acetate)

Bazedoxifene (acetate) is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERalpha (IC50 = 26 nM) and ERbeta (IC50 = 99 nM). Bazedoxifene (actetate) antagonizes 17beta-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as well as hormone-independent growth of MCF-7:5C cells that are resistant to long-term estrogen deprivation (80% reduction with 10 nM). It has been shown to arrest cell cycling by downregulating cyclin D1 and ERalpha.Formal Name: 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol, acetate. CAS Number: 198481-33-3. Synonyms: TSE 424. Molecular Formula: C30H34N2O3 . C2H4O2. Formula Weight: 530.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS (pH 7.2) (1:20): 0.04 mg/ml, DMSO: 14 mg/ml, Ethanol: 5 mg/ml. lambdamax: 227, 299 nm. SMILES: CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=C1C=C(O)C=C5.CC(O)=O. InChi Code: InChI=1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31,1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3,1H3,(H,3,4). InChi Key: OMZAMQFQZMUNTP-UHFFFAOYSA-N.