BAY 43-9006

BAY 43-9006
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009644-1 1 mg -

1 - 10 business days

32.00€
Cay10009644-5 5 mg -

1 - 10 business days

63.00€
Cay10009644-10 10 mg -

1 - 10 business days

94.00€
Cay10009644-50 50 mg -

1 - 10 business days

298.00€
 
Sorafenib is an inhibitor of Raf-1 and B-RAF (IC50s = 6 and 22 nM, respectively), as well as... more
Product information "BAY 43-9006"
Sorafenib is an inhibitor of Raf-1 and B-RAF (IC50s = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It poorly inhibits ERK1, MEK1, and several other kinases (IC50s = >10 µM). It inhibits tumor angiogenesis and induces tumor cell apoptosis, particularly in renal cell carcinoma and hepatocellular carcinoma. Sorafenib (10 µM) also induces ferroptotic cell death in HT-1080 fibrosarcoma cells, an effect that can be blocked by the ferroptosis inhibitors ferrostatin-1 (Cay-17729), deferoxamine (Cay-14595), and beta-mercaptoethanol. It inhibits glutamate release by the system Xc- cystine-glutamate transporter in HT-1080 cells when used at concentrations ranging from 2.5 to 10 µM, decreases glutathione levels, and increases lipid peroxidation. However, sorafenib induces ferrostatin-1-suppressible ferroptosis only within a narrow range of concentrations in HT-1080 cells (EC50s = 18 and 43 µM without and with ferrostatin-1, respectively) and does not induce ferrostatin-1-suppressible ferroptosis in several other cell lines.
Keywords: Sorafenib, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Supplier: Cayman Chemical
Supplier-Nr: 10009644-1

Properties

Application: Kinase inhibitor
MW: 464.8 D
Formula: C21H16ClF3N4O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 284461-73-0| Search using CAS
KEGG ID : K04366 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H360, H362, H373, H413
P Phrases: P201, P202, P260, P263, P264, P270, P273, P280, P314, P308+P313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "BAY 43-9006"
Write a review
or to review a product.
Viewed