Sorafenib, Free Base (BAY-43-9006)

Sorafenib, Free Base (BAY-43-9006)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
S5343-01.1 1 g - -

3 - 19 business days*

282.00€
S5343-01.5 5 g - -

3 - 19 business days*

428.00€
S5343-01.10 10 g - -

3 - 19 business days*

704.00€
 
Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by... more
Product information "Sorafenib, Free Base (BAY-43-9006)"
Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-b and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor (IC50=6nM), it has since been shown to have activity against many receptor tyrosine kinases involved in tumorigenesis and angiogenesis including FGFR-1, wt BRAF and V599E mutant BRAF, as well as members of the so-called "split kinase" family: VEGFR-2, VEGFR-3, PDGFR-b, c-KIT, and Flt3. However, sorafenib is not active against erbB1, erbB2, ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-MET, c-yes, PKB, PKA, cdk1/cyclinB, PKC, and pim-1. In cellular mechanistic assays, sorafenib decreased basal phosphorylation of the ERK pathway in melanoma, breast, colon, and pancreatic tumor cell lines. Appearance: Supplied as an off-white powder. Purity: HPLC: >99%, TLC: >99%, Solubility: Soluble in DMSO at 200mg/ml, soluble in ethanol at 3.3mg/ml with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-50uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Melting Point: 204-206.5°C, Elemental Anaylsis: Calculated: , C=54.26%, H=3.47%, Cl=7.63%, F=12.26%, N=12.05%, Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: S5343-01

Properties

MW: 464.82
Formula: C21H16ClF3N4O3
Purity: ~98%
Format: Highly Purified

Database Information

CAS : 284461-73-0| Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Sorafenib, Free Base (BAY-43-9006)"
Write a review
or to review a product.
Sorafenib Sorafenib
From 104.00€ *
-10 %
BAY 43-9006 BAY 43-9006
17.00€ * From 15.30€ *
Sorafenib Sorafenib
From 43.00€ *
Viewed