6 products were found matching "284461-73-0"!

Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It is selective for these kinases over 12 other kinases, including ERK1,...

c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.

Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-b and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor...

Antitumor compound, Broad-spectrum kinase inhibitor, Raf kinase inhibitor, Apoptosis inducer, Cytostatic, Angiogenesis inhibitor, Review.

Soluble in DMSO at 200 mg/mL, soluble in ethanol at 3.3 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-50 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility

Sorafenib Tosylate, also known as Bay 43-9006, is a novel bi-aryl urea compound that inhibits cell proliferation by targeting receptor tyrosine kinases, including VEGFR-2 and PDGFR-ß and their associated signaling cascades of the ERK pathway and angiogenesis. It was originally developed as a Raf kinase inhibitor. It...