BAY 41-2272

Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain. The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM. Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle. BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats. Unlike another sGC activator, YC-1 (Cay-81560), BAY 41-2772 does not inhibit phosphodiesterases.Formal Name: 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine. CAS Number: 256376-24-6. Molecular Formula: C20H17FN6. Formula Weight: 360.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16.6 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml, DMSO: 12.5 mg/ml, Ethanol: 0.16 mg/ml. lambdamax: 214, 255, 322 nm. SMILES: FC(C=CC=C1)=C1CN2N=C(C3=NC=C(C4CC4)C(N)=N3)C5=CC=CN=C52. InChi Code: InChI=1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25). InChi Key: ATOAHNRJAXSBOR-UHFFFAOYSA-N.