42 products were found matching "K12319"!
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ODQ
Item number: Cay81410-5
ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase. The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.Formal Name: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. CAS...
| Keywords: | 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one |
| Application: | Guanylyl cyclase inhibitor |
| CAS | 41443-28-1 |
| MW: | 187.2 D |
From 54.00€
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Anti-Guanylate Cyclase beta1 subunit (soluble)
Item number: Cay160897-1
Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein and nitric oxide (NO) sensor composed of two subunits, alpha1 and beta1. The approximately 70 kDa sGC beta1 subunit is encoded by GUCY1B3 in humans, ubiquitously expressed, and localized to the cytosol. The sGC histidine residue at position 105 is...
| Keywords: | Anti-Guc1b3, Anti-Gucy1b1, Anti-GCS-beta-1, Anti-GCS-beta-3, Anti-GCS-beta-1, Anti-GCS-beta-3, Anti-Soluble guanylate... |
| Application: | IHC, WB |
| Host: | Rabbit |
| Species reactivity: | rat |
468.00€
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YC-1
Item number: Cay81560-5
YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM, respectively. In the absence of NO or carbon monoxide (CO), 200 µM YC-1 increases the activity of...
| Keywords: | 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol |
| Application: | Platelet aggregation inhibitor |
| CAS | 170632-47-0 |
| MW: | 304.3 D |
From 27.00€
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Riociguat
Item number: Cay9000554-5
Riociguat is a stimulator of soluble guanylate cyclase (sGC)., It stimulates recombinant sGC in a concentration-dependent manner in vitro by up to 73-fold when used at a concentration of 100 µM or by up to 112-fold when used in combination with the nitric oxide (NO) donor DEA NONOate (Cay-82100). It has no effect on...
| Keywords: | BAY 63-2521, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbamic... |
| Application: | Soluble guanylate cyclase activator |
| CAS | 625115-55-1 |
| MW: | 422.4 D |
From 127.00€
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Ataciguat
Item number: Cay16371-5
Soluble guanylate cyclase (sGC) is the primary cellular receptor for NO. NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cGMP. cGMP subsequently mediates a number of signaling cascades leading to vasorelaxation and inhibiting smooth muscle proliferation, leukocyte...
| Keywords: | HMR 1766, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-benzamide |
| Application: | sGC, oxidized, heme-free, form, activator |
| CAS | 254877-67-3 |
| MW: | 576.5 D |
From 122.00€
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BAY 41-2272
Item number: Cay10057-5
Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain. The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine...
| Keywords: | 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine |
| Application: | Soluble guanylate cyclase activator |
| CAS | 256376-24-6 |
| MW: | 360.4 D |
From 158.00€
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Cinaciguat (hydrochloride)
Item number: Cay17468-500
Soluble guanylate cyclase (sGC) is the primary cellular receptor for NO. NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cGMP. cGMP subsequently mediates a number of signaling cascades leading to vasorelaxation and inhibiting smooth muscle proliferation, leukocyte...
| Keywords: | BAY 58-2667, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid,... |
| Application: | Soluble guanylate cyclase activator |
| CAS | 646995-35-9 |
| MW: | 602.2 D |
From 85.00€
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NS 2028
Item number: Cay81600-5
NS 2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse...
| Keywords: | 8-bromo-4H-2,5-dioxa-3,9b-diaza-cyclopenta[a]naphthalen-1-one |
| Application: | Guanylyl cyclase inhibitor |
| CAS | 204326-43-2 |
| MW: | 269.1 D |
From 71.00€
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Anti-Guanylyl Cyclase beta
Item number: ARG10821.50
Protein function: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. [The UniProt Consortium]
| Keywords: | Anti-Guc1b3, Anti-Gucy1b3, Anti-GCS-beta-1, Anti-GCS-beta-3, Anti-Soluble guanylate cyclase small subunit, Anti-Guanylate... |
| Application: | IF, ELISA, ICC, IF, IHC (paraffin), IP, WB, DB |
| Host: | Rabbit |
| Species reactivity: | bovine, human, mouse, swine, rat |
608.00€
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Anti-Guanylate Cyclase beta1
Item number: ARG56512.250
Protein function: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. [The UniProt Consortium]
| Keywords: | Anti-Guc1b3, Anti-Gucy1b3, Anti-GCS-beta-3, Anti-GCS-beta-1, Anti-Soluble guanylate cyclase small subunit, Anti-Guanylate... |
| Application: | IHC, WB |
| Host: | Rabbit |
| Species reactivity: | human, rat, bovine |
707.00€
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YC-1
Item number: LKT-Y0800.1
Guanylyl cyclase activator and HIF-1alpha inhibitor.
| Keywords: | 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole |
| Application: | Guanylyl cyclase activator and HIF-1alpha inhibitor |
| CAS | 170632-47-0 |
| MW: | 304.35 D |
From 65.00€
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Anti-Guanylyl Cyclase beta
Item number: ARG59608.100
Protein function: Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. [The UniProt Consortium]
| Keywords: | Anti-GUC1B3, Anti-GCS-beta-1, Anti-GCS-beta-3, Anti-Soluble guanylate cyclase small subunit, Anti-Guanylate cyclase... |
| Application: | WB |
| Host: | Rabbit |
| Species reactivity: | mouse, rat |
707.00€
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