AZD 7624

AZD 7624 is an inhibitor of p38alpha MAPK signaling. AZD 7624 (1 µM), in combination with the synthetic glucocorticoid dexamethasone (Cay-11015), prevents LPS-induced increases in the levels of TNF-alpha and IL-6 secreted from primary human alveolar macrophages isolated from patients with chronic obstructive pulmonary disease (COPD).Formal Name: N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-benzamide. CAS Number: 1095004-78-6. Molecular Formula: C27H30FN5O3. Formula Weight: 491.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, Methanol: Soluble. SMILES: CNCCOC1=CC=CC=C1C2(CC2)NC3=NC=CN(C4=CC(C(NC5CC5)=O)=CC(F)=C4C)C3=O. InChi Code: InChI=1S/C27H30FN5O3/c1-17-21(28)15-18(25(34)31-19-7-8-19)16-22(17)33-13-11-30-24(26(33)35)32-27(9-10-27)20-5-3-4-6-23(20)36-14-12-29-2/h3-6,11,13,15-16,19,29H,7-10,12,14H2,1-2H3,(H,30,32)(H,31,34). InChi Key: NNKPHNTWNILINE-UHFFFAOYSA-N.