AWD 131-138

AWD 131-138 is a partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM. This effect is blocked by the benzodiazepine antagonist flumazenil (Cay-14252). AWD 131-138 displays a broad spectrum of anticonvulsant activity in diverse seizure and epilepsy models without a tendency toward tolerance or abuse. It has a superior pharmacokinetic profile in dogs vs. humans.Formal Name: 1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one. CAS Number: 188116-07-6. Synonyms: ELB138, Imepitoin. Molecular Formula: C13H14ClN3O2. Formula Weight: 279.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 229, 271 nm. SMILES: O=C1N(C2=CC=C(Cl)C=C2)CC(N3CCOCC3)=N1. InChi Code: InChI=1S/C13H14ClN3O2/c14-10-1-3-11(4-2-10)17-9-12(15-13(17)18)16-5-7-19-8-6-16/h1-4H,5-9H2. InChi Key: IQHYCZKIFIHTAI-UHFFFAOYSA-N.