24 products were found matching "K05770"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TSPO. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TSPO. Next,...

Benzodiazepines bind two types of receptors, the central gamma-aminobutyric acid A receptor and the peripheral translocator protein (TSPO). PK11195 binds the peripheral benzodiazepine receptor, TSPO, with selectivity and high affinity (Ki = 3.1 nM in cerebellum, 4.1 nM in spinal cord). PK11195, which lacks the...

Protein function: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required...

Protein function: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor, can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Translocator protein (18kDa), PBR, peripheral benzodiazepine receptor Protein function: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Peripheral benzodiazepine receptor, translocator protein (18kDa), Tspo Protein function: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially...

Selective peripheral benzodiazepine antagonist, Apoptosis enhancer, Glucose-induced insulin secretion inhibitor, Induces mitochondria cytochrome c release, Anticancer compound, Antiproliferative, Pharmacological tool in autophagy.

AWD 131-138 is a partial agonist of the GABAA receptor that acts at the benzodiazepine binding site, dose-dependently stimulating GABA currents with a threshold of 0.3-1.0 µM. This effect is blocked by the benzodiazepine antagonist flumazenil (Cay-14252). AWD 131-138 displays a broad spectrum of anticonvulsant...

AC-5216 is a high affinity agonist of the 18 kDa translocator protein (TSPO, previously called the peripheral benzodiazepine receptor) that exhibits a Ki value of 0.297 nM in rat whole brain and IC50 values of 2.73 and 3.04 nM, respectively, against human and rat glial TSPO. AC-5216 produces anxiolytic and...

FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO, previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM. It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone (Cay-16930). Through this action, FGIN-1-27...

DAA1106 is an agonist of the 18 kDa translocator protein TSPO, which was previously known as the peripheral benzodiazepine receptor (PBR), that has an IC50 value of 0.28 nM in a radioligand binding assay. It is selective for TSPO over central benzodiazepine receptors (CBRs) and GABAA receptors in rat whole brain...