AT7867

AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC50s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.Formal Name: 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-piperidine. CAS Number: 857531-00-1. Molecular Formula: C20H20ClN3. Formula Weight: 337.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.33 mg/ml. lambdamax: 258 nm. SMILES: ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C4=CNN=C4)C=C3. InChi Code: InChI=1S/C20H20ClN3/c21-19-7-5-18(6-8-19)20(9-11-22-12-10-20)17-3-1-15(2-4-17)16-13-23-24-14-16/h1-8,13-14,22H,9-12H2,(H,23,24). InChi Key: LZMOSYUFVYJEPY-UHFFFAOYSA-N.