AT7519 hydrochloride

AT7519 hydrochloride
Item number Size Datasheet Manual SDS Delivery time Quantity Price
SYN-1010-M001 1 mg -

3 - 9 business days*

79.00€
SYN-1010-M005 5 mg -

3 - 9 business days*

132.00€
SYN-1010-M010 10 mg -

3 - 9 business days*

198.00€
SYN-1010-M050 50 mg -

3 - 9 business days*

711.00€
SYN-1010-M100 100 mg -

3 - 9 business days*

-
 
Soluble in DMSO or ethanol. AT7519 is a potent inhibitor of several CDK family members. AT7519... more
Product information "AT7519 hydrochloride"
Soluble in DMSO or ethanol. AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519 caused cell cycle arrest followed by apoptosis in human tumor cells and inhibited tumor growth in human tumor xenograft models. Tumor regression was observed following twice daily dosing of AT7519 in the HCT116 and HT29 colon cancer xenograft models. Also it has been shown that the biological effects are linked to inhibition of CDKs in vivo and that AT7519 induces tumor cell apoptosis in these xenograft models. Moreover, AT7519 has an attractive biological profile and is well tolerated and effective making it a more plausible candidate for clinical development than previously available CDK inhibitors. In in vitro kinase assays AT7519 showed nanomolar levels of activity from <10 to 2400 for cyclins, only one other non-cyclin related kinase was inhibited at levels below 10µM (GSK3beta, 89nM), all others tested had IC(50)'s of greater than 10,000nM. Target: CDK2 - CDK7 - CDK5 - CDK4 , Kinase Group: CMGC , Substrate: Serine-Threonine
Keywords: AT-7519
Supplier: SYNkinase
Supplier-Nr: 1010

Properties

Application: CDK2 / CDK7 / CDK5 / CDK4 inhibitor
MW: 418,7 D
Formula: C16H17Cl2N5O2 . HCl
Purity: >95%
Format: Solid

Database Information

CAS : 902135-91-5| Matching products
KEGG ID : K02206 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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