ARN24139

ARN24139 is a topoisomerase II poison (IC50 = 7.3 µM in a topoisomerase II decatenation assay). It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 µM, respectively).Formal Name: 6-hydroxy-4-oxo-1,3-diphenyl-2-thioxo-N-(3-(trifluoromethoxy)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide. CAS Number: 2699768-78-8. Molecular Formula: C24H16F3N3O4S. Formula Weight: 499.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 10 mg/ml. lambdamax: 239, 321 nm. SMILES: O=C(C1C(N(C(N(C2=CC=CC=C2)C1=O)=S)C3=CC=CC=C3)=O)NC4=CC(OC(F)(F)F)=CC=C4. InChi Code: InChI=1S/C24H16F3N3O4S/c25-24(26,27)34-18-13-7-8-15(14-18)28-20(31)19-21(32)29(16-9-3-1-4-10-16)23(35)30(22(19)33)17-11-5-2-6-12-17/h1-14,19H,(H,28,31). InChi Key: MGLUIWLWLIJXMY-UHFFFAOYSA-N.