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Anle138b is an inhibitor of protein aggregation. It inhibits alpha-synuclein oligomer formation and PrPSc prion propagation by 77 and 84%, respectively, when used at a concentration of 10 µM. Anle138b (1 mg/animal) inhibits brain accumulation of PrPSc in, and increases survival of, prion-infected mice. It reduces brain tau deposition and rescues glucose metabolic decline in a human tau transgenic mouse model of Alzheimer's disease. Dietary administration of anle138b (0.6 and 2 g/kg chow) reduces the formation of alpha-synuclein oligomers and glial cytoplasmic inclusions, microglial activation, and dopaminergic neuron degradation, as well as preserves motor function, in a mouse model of multiple system atrophy (MSA).Formal Name: 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole. CAS Number: 882697-00-9. Molecular Formula: C16H11BrN2O2. Formula Weight: 343.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. SMILES: BrC1=CC=CC(C2=CC(C3=CC=C4C(OCO4)=C3)=NN2)=C1. InChi Code: InChI=1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19). InChi Key: RCQIIBJSUWYYFU-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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