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ANA-12 is a TrkB receptor antagonist that prevents activation of the receptor by BDNF with IC50 values of 45.6 nM and 41.1 µM for the high and low affinity sites of the receptor, respectively. It does not affect TrkA or TrkC in an assay of neurite outgrowth. Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans.Formal Name: N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide. CAS Number: 219766-25-3. Molecular Formula: C22H21N3O3S. Formula Weight: 407.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: :, DMF: 5 mg/ml, DMSO: 5 mg/ml. lambdamax: 247, 299, 315 nm. SMILES: O=C(NC1C(NCCCC1)=O)C2=CC=CC=C2NC(C3=CC4=C(C=CC=C4)S3)=O. InChi Code: InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26). InChi Key: TUSCYCAIGRVBMD-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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